Reducing Inflammation with Fisetin

“Inflammaging” is a combination of “inflammation” and “ageing” – chronic, low-grade inflammation that occurs as a result of the ageing process.

The exact mechanisms behind inflammaging are not fully understood, but it is thought to be caused by a combination of genetic, environmental, and lifestyle factors (diet, exercise, stress, rest).

Inflamed joints can be caused by a variety of factors, including:

  1. Autoimmune disorders: In conditions like rheumatoid arthritis and lupus, the immune system mistakenly attacks the body’s own tissues, including the joints.
  2. Infection: Bacterial, viral, or fungal infections can cause joint inflammation.
  3. Injury: Damage to the joint, such as a sprain or fracture, can cause inflammation.
  4. Overuse: Repeated stress on the joint, as seen in athletes or manual labourers, can cause inflammation.
  5. Gout: A type of arthritis caused by a buildup of uric acid crystals in the joints.
  6. Osteoarthritis: A degenerative joint disease that causes the breakdown of cartilage and leads to inflammation.
  7. Aging: As we age, joints naturally wear down and become more prone to inflammation.

Inflammation in joints can lead to pain, stiffness, and reduced mobility. Treatment for inflamed joints depends on the underlying cause and may include medications, supplements, physical therapy, and lifestyle modifications.

A build-up of Senescent cells is one of the 9 Hallmarks of Aging

When cells become senescent, they stop dividing and start to accumulate in tissues. These cells secrete a complex mixture of proteins, lipids, and other molecules called the senescence-associated secretory phenotype (SASP). The SASP includes various pro-inflammatory cytokines, chemokines, and other factors that can promote inflammation and tissue damage. Simply put, senescent cells accumulate with age and cause inflammation.

The accumulation of senescent cells and the associated inflammation have been linked to various age-related diseases, including cancer, cardiovascular disease, and neurodegenerative diseases. Therefore, targeting senescent cells and reducing inflammation associated with the SASP has emerged as a promising strategy for combating age-related diseases and promoting healthy ageing.

Recent research has shown that Fisetin, a natural flavonoid compound found in some fruits (especially strawberries!) and vegetables, can selectively kill senescent cells and reduce the associated inflammation. Fisetin has been shown to have potential anti-aging effects and may be useful in preventing or treating age-related diseases by targeting senescent cells and reducing inflammation. However, more research is needed to fully understand the mechanisms involved and to determine optimal dosages and potential side effects in humans.

Senolytics are compounds that support the body’s natural ability to clear old, damaged (senescent) cells to make way for new, healthy cells.

Fisetin, a flavonoid found in various plants and in minute quantities in some fruits and vegetables, is one of the most powerful natural senolytics ever discovered.

Learn about Matakana Fisetin Ultra – a senolytic available from Matakana Superfoods or get it direct from me (NZD$65 – April 2023)

What is a Senolytic?

Senolytics have been developed as a potential therapy to target senescent cells and improve health outcomes in older adults. These drugs work by triggering cell death in senescent cells, while sparing healthy cells. By removing these senescent cells from the body, senolytics have been shown to improve tissue function, reduce inflammation, and increase lifespan in preclinical studies.

Senolytics are still in the early stages of development and research, and there is much to be learned about their safety and efficacy in humans. However, they represent an exciting potential avenue for treating age-related diseases and improving health outcomes in older adults.

Please note that your doctor may not know much/anything about Fisetin. It is relatively newly discovered and while early research suggests it should have significant benefits for humans, there are not many significant, completed studies yet. However, it is a naturally occurring compound and there are currently no known negative side effects. (March 23)

Click here to learn more about Fisetin, its benefits and side effects

Click here to learn about clinical studies conducted on Fisetin

Click here to learn about current and planned clinical trials on Fisetin

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